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Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features PDF Author: Eric Murillo-Rodríguez
Publisher: Bentham Science Publishers
ISBN: 1608050289
Category : Medical
Languages : en
Pages : 223

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Book Description
The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1 and CB2 receptors) activated by marijuana’s psychoactive principle ∆9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail.

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features PDF Author: Eric Murillo-Rodríguez
Publisher: Bentham Science Publishers
ISBN: 1608050289
Category : Medical
Languages : en
Pages : 223

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Book Description
The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1 and CB2 receptors) activated by marijuana’s psychoactive principle ∆9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail.

Behavioral Neurobiology of the Endocannabinoid System

Behavioral Neurobiology of the Endocannabinoid System PDF Author: Dave Kendall
Publisher: Springer Science & Business Media
ISBN: 9783540889557
Category : Medical
Languages : en
Pages : 420

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Book Description
The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior.

The Endocannabinoid System

The Endocannabinoid System PDF Author: Eric Murillo-Rodríguez
Publisher: Academic Press
ISBN: 0128096675
Category : Nature
Languages : en
Pages : 256

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Book Description
The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases Includes well-written overviews of the basics of endocannabinoid system structure and function Contains well-illustrated material, with diagrams, charts, and tables Explores compelling case studies and their application to chapters written by experts

The Endocannabinoid System in Local and Systemic Inflammation

The Endocannabinoid System in Local and Systemic Inflammation PDF Author: Melanie E. M. Kelly
Publisher: Biota Publishing
ISBN: 1615047492
Category : Medical
Languages : en
Pages : 209

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Book Description
This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

THE ENDOCANNABINOID SYSTEM: THE KEY TO LIFE

THE ENDOCANNABINOID SYSTEM: THE KEY TO LIFE PDF Author: Pharmacology University
Publisher: Pharmacology University
ISBN:
Category : Health & Fitness
Languages : en
Pages : 36

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Book Description
The endocannabinoid system (ECS) has been a revolutionary discovery in recent years. Thanks to this system, we can understand how cells, tissues, and organs of the human body communicate with each other through its components. This has been evidenced in its important role as a modulator, regulator, and signaling in different metabolic processes that influence the balance and maintenance of the physiological functions of the organism. The study of this system facilitates the understanding of events and processes developed in the body and how phytocannabinoids help to improve a wide variety of disturbances and disorders that can be physical and psychological. Join us on this journey to explore the history, discovery, composition, and interactions of the endocannabinoid system with the different systems of the human body, as well as its importance as a pharmacological target for cannabis derivatives and advances at the medicinal level, in the search for new therapies for the treatment of multiple diseases. Would you like to know more about the endocannabinoid system and its components? Visit Pharmacology University's social networks and dive into the wide collection of ebooks and audiobooks we have prepared for you.

The endocannabinoid system: a key modulator of emotions and cognition

The endocannabinoid system: a key modulator of emotions and cognition PDF Author: Patrizia Campolongo
Publisher: Frontiers E-books
ISBN: 2889190854
Category :
Languages : en
Pages : 142

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Book Description


The Body Systems and the Endocannabinoid System (ECS)

The Body Systems and the Endocannabinoid System (ECS) PDF Author: Elise Bailey
Publisher: ECS Training Alliance Press
ISBN:
Category : Medical
Languages : en
Pages : 45

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Book Description
This exciting little book is a unique reference guide to the different body systems and the role that the endocannabinoid system (ECS) plays in each. With so many people using cannabinoids and terpenes it is important to understand how these things can influence body signaling. This book is easy to follow with beautiful visual diagrams and important scientific references. It is great for anyone wanting to learn how to better understand the role of the ECS in each body system. The information is intended to assist the reader to gain a basic understanding of the influential role the ECS plays in the body. It has been created for those that want to tap into the ECS using cannabinoids, terpenes, therapeutic grade essential oils, and vital nutrients. It is biology made easy and created for a consumer market. Created by Biologist Elise Bailey The ECS Training Alliance

The Endocannabinoid System: Filling the Translational Gap between Neuroscience and Psychiatry

The Endocannabinoid System: Filling the Translational Gap between Neuroscience and Psychiatry PDF Author: Marco Colizzi
Publisher: Frontiers Media SA
ISBN: 2889741486
Category : Medical
Languages : en
Pages : 139

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Book Description


Cannabinoids

Cannabinoids PDF Author: Vincenzo Di Marzo
Publisher: John Wiley & Sons
ISBN: 1118451279
Category : Science
Languages : en
Pages : 320

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Book Description
‘Cannabinoids’ is a broad term covering a group ofnatural products from Cannabis sativa, one of which locks on tospecific receptors – protein molecules on the surface ofcells – known as cannabinoid receptors. Over the past decadesscientists have found that cannabinoid receptors and theirendogenous ligands, the endocannabinoids, are involved in a vastarray of physiological functions, including helping to controlbrain activity, energy metabolism, heart function, the immunesystem and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributionsfrom international experts to provide the definitive guide to whatcontinues to be a rapidly developing research field. After anintroductory historical chapter, the book continues by looking atthe biochemical, genetic and molecular elements of cannabinoids,followed by chapters covering their role in health anddisease. The final chapter outlines the need for a newnomenclature to reflect the complex and multi-disciplinary natureof this area.

Cannabinoids as Therapeutics

Cannabinoids as Therapeutics PDF Author: Raphael Mechoulam
Publisher: Springer Science & Business Media
ISBN: 9783764370558
Category : Medical
Languages : en
Pages : 302

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Book Description
Only a few years ago the endocannabinoid system was unknown. Today we are aware that endocannabinoids are involved in many of the functions of the mammalian body - in neuroprotection, appetite and suckling, pain, reproduction, anxiety, memory, bone formation etc. This volume presents an up-to-date picture of some of the major fields of endocannabinoid research. It summarizes the actions of the endocannabinoids on various physiological systems and opens new therapeutic windows to a large number of diseases. The first chapter, on the use of Cannabis in India, can be viewed as an expression of thanks to the herbal practitioners, who for centuries passed on the medical traditions associated with the drug. The chapter on chemistry is a short summary of active plant, synthetic and endogenous cannabinoids being investigated today, many of which are mentioned later in the book. Cannabidiol is an unusual cannabinoid - it does not bind to the known receptors and yet exerts a variety of effects. Hence a chapter is devoted to it. Further chapters deal with the endocannabinoid system and the endocannabinoids in a variety of conditions and physiological systems. The concluding chapter describes the research done on Sativex®, a standardized plant extract, shortly to be introduced in Canada as a drug for multiple sclerosis. The intended audience is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians interested in the effect of the endocannabinoid system in various physiological systems.