Influenza Virus Vaccines and Immunotherapies PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Influenza Virus Vaccines and Immunotherapies PDF full book. Access full book title Influenza Virus Vaccines and Immunotherapies by Arun Kumar. Download full books in PDF and EPUB format.

Influenza Virus Vaccines and Immunotherapies

Influenza Virus Vaccines and Immunotherapies PDF Author: Arun Kumar
Publisher: Frontiers Media SA
ISBN: 2889198111
Category :
Languages : en
Pages :

Get Book

Book Description
Influenza virus infections lead to thousands of deaths worldwide annually and billions of dollars economic burden. Despite continuing advances in our understanding of the immune evasion mechanism, the disease remains one of the foremost threat for human being. Traditional vaccines (attenuated and inactivated) mainly provide protection by inducing virus neutralizing antibodies, targeting ever changing surface antigens: Haemagultinin (HA) and Neuraminidase (NA). Due to genetic shift and immune selection pressure, prevalence of circulating influenza virus subtypes changes every year. Therefore, mismatch between circulating strain and vaccine strain can critically affect the success rate of these conventional flu vaccines, and requires continuous monitoring of circulating influenza virus subtypes and change in the vaccine formulations accordingly. The collective limitations of existing flu vaccines urgently call for the development of a novel universal vaccines that might provide the required protective immunity to a range of influenza virus subtypes. New approaches are being investigated mainly targeting conserved regions of flu proteins. Some of these approaches include universally conserved epitopes of HA, nucleoprotein (NP), capsid protein (M1) and ion channel protein (M2) that induced strong immune responses in animal models. Some attention and progress appears to be focused on vaccines based on the M2 ectodomain (M2e) employing a variety of constructs, adjuvants and delivery systems, including M2e-hepatitis B core antigen, flagellin constructs, and virus-like particles (VLP). Animal studies with these M2e candidate vaccines demonstrated that these vaccine candidates can prevent severe illness and death but not infection, which may pose difficulties in both the evaluation of clinical efficacy and approval by the regulatory authorities. VLP vaccines appear to be promising, but still are mostly limited to animal studies. The discovery and development of new and improved vaccines have been greatly facilitated by the application of new technologies. The use of nucleic acid-based vaccines, to combine the benefits of in-situ expression of antigens with the safety of inactivated and subunit vaccines, has been a key advancement. Upon their discovery more than 20 years ago, nucleic acid vaccines promised to be a safe and effective mean to mimic immunization with a live organism vaccine, particularly for induction of T cell immunity. In addition, the manufacturing of nucleic acid-based vaccines offered the potential to be relatively simple, inexpensive and generic. Reverse Vaccinology and in-silico designing of vaccines are very innovative approaches and being considered as future of vaccines. Furthermore, various immuno-therapeutic agents also being developed to treat and minimize immuno-pathological damage in patients suffering from life threatening complications. For the treatment of such pathological conditions, various novel approaches such as administration of immune suppressive cytokines, blocking co-stimulatory signals or activating co-inhibitory signal of T cell activation, are being tested both in lab and clinics. The Research Topic on influenza virus vaccine and therapeutics will give an insight in to the current status and future scope of these new innovative approaches and technologies. Moreover, these new methods will also serve as a reference tool for the development of future vaccines against several other pathogens.

Influenza Virus Vaccines and Immunotherapies

Influenza Virus Vaccines and Immunotherapies PDF Author: Arun Kumar
Publisher: Frontiers Media SA
ISBN: 2889198111
Category :
Languages : en
Pages :

View

Book Description
Influenza virus infections lead to thousands of deaths worldwide annually and billions of dollars economic burden. Despite continuing advances in our understanding of the immune evasion mechanism, the disease remains one of the foremost threat for human being. Traditional vaccines (attenuated and inactivated) mainly provide protection by inducing virus neutralizing antibodies, targeting ever changing surface antigens: Haemagultinin (HA) and Neuraminidase (NA). Due to genetic shift and immune selection pressure, prevalence of circulating influenza virus subtypes changes every year. Therefore, mismatch between circulating strain and vaccine strain can critically affect the success rate of these conventional flu vaccines, and requires continuous monitoring of circulating influenza virus subtypes and change in the vaccine formulations accordingly. The collective limitations of existing flu vaccines urgently call for the development of a novel universal vaccines that might provide the required protective immunity to a range of influenza virus subtypes. New approaches are being investigated mainly targeting conserved regions of flu proteins. Some of these approaches include universally conserved epitopes of HA, nucleoprotein (NP), capsid protein (M1) and ion channel protein (M2) that induced strong immune responses in animal models. Some attention and progress appears to be focused on vaccines based on the M2 ectodomain (M2e) employing a variety of constructs, adjuvants and delivery systems, including M2e-hepatitis B core antigen, flagellin constructs, and virus-like particles (VLP). Animal studies with these M2e candidate vaccines demonstrated that these vaccine candidates can prevent severe illness and death but not infection, which may pose difficulties in both the evaluation of clinical efficacy and approval by the regulatory authorities. VLP vaccines appear to be promising, but still are mostly limited to animal studies. The discovery and development of new and improved vaccines have been greatly facilitated by the application of new technologies. The use of nucleic acid-based vaccines, to combine the benefits of in-situ expression of antigens with the safety of inactivated and subunit vaccines, has been a key advancement. Upon their discovery more than 20 years ago, nucleic acid vaccines promised to be a safe and effective mean to mimic immunization with a live organism vaccine, particularly for induction of T cell immunity. In addition, the manufacturing of nucleic acid-based vaccines offered the potential to be relatively simple, inexpensive and generic. Reverse Vaccinology and in-silico designing of vaccines are very innovative approaches and being considered as future of vaccines. Furthermore, various immuno-therapeutic agents also being developed to treat and minimize immuno-pathological damage in patients suffering from life threatening complications. For the treatment of such pathological conditions, various novel approaches such as administration of immune suppressive cytokines, blocking co-stimulatory signals or activating co-inhibitory signal of T cell activation, are being tested both in lab and clinics. The Research Topic on influenza virus vaccine and therapeutics will give an insight in to the current status and future scope of these new innovative approaches and technologies. Moreover, these new methods will also serve as a reference tool for the development of future vaccines against several other pathogens.

Heterologous Immunity: Implications and Applications in Vaccines and Immunotherapies

Heterologous Immunity: Implications and Applications in Vaccines and Immunotherapies PDF Author: Babita Agrawal
Publisher: Frontiers Media SA
ISBN: 2889639657
Category :
Languages : en
Pages :

View

Book Description


Antiviral Agents, Vaccines, and Immunotherapies

Antiviral Agents, Vaccines, and Immunotherapies PDF Author: Stephen Tyring
Publisher: CRC Press
ISBN: 9780824754082
Category : Medical
Languages : en
Pages : 440

View

Book Description
Unlike any other source on the subject, Antiviral Agents, Vaccines, and Immunotherapies analyzes the benefits and limitations of every available drug, vaccine, and immunotherapy utilized in the prevention and control of viral diseases. This reference provides in-depth reviews of more than 50 drugs and antiviral agents for HIV, human herpesviruses, human papillomaviruses (HPV), influenza, respiratory syncytial virus, hepatitis B, and analyzes their mechanisms of action, dosage, side effects, and drug resistance. The book also provides an overview of the use of immunoglobulins and monoclonal antibodies for antiviral use and supplies extensive references, tables, and figures throughout the text.

Advances in Active Immunotherapy Research and Application: 2012 Edition

Advances in Active Immunotherapy Research and Application: 2012 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1481604880
Category : Medical
Languages : en
Pages : 95

View

Book Description
Advances in Active Immunotherapy Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Active Immunotherapy in a concise format. The editors have built Advances in Active Immunotherapy Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Active Immunotherapy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Active Immunotherapy Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Novel Technologies for Vaccine Development

Novel Technologies for Vaccine Development PDF Author: Igor S Lukashevich
Publisher: Springer
ISBN: 3709118182
Category : Medical
Languages : en
Pages : 386

View

Book Description
This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Vaccine Design

Vaccine Design PDF Author: Gregory Gregoriadis
Publisher: Springer Science & Business Media
ISBN: 1489900624
Category : Medical
Languages : en
Pages : 209

View

Book Description
Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996

Cancer Vaccines and Immunotherapy

Cancer Vaccines and Immunotherapy PDF Author: Peter L. Stern
Publisher: Cambridge University Press
ISBN: 9780521622639
Category : Medical
Languages : en
Pages : 286

View

Book Description
This book provides an essential introduction and guide for oncologists, immunologists and clinicians treating cancer patients.

Vaccines: Advances in Research and Application: 2011 Edition

Vaccines: Advances in Research and Application: 2011 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1464929599
Category : Medical
Languages : en
Pages : 149

View

Book Description
Vaccines: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Vaccines. The editors have built Vaccines: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Vaccines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Vaccines: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Vaccines, Vaccination, and the Immune Response

Vaccines, Vaccination, and the Immune Response PDF Author: Ada Gordon
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Medical
Languages : en
Pages : 247

View

Book Description
This volume reviews current work on new vaccines and defines the key immunological principles that govern vaccine development. The opening section describes current vaccines and those in late-stage clinical trials, surveys national and international immunization programmes and highlights future needs and opportunities in vaccine development. A major portion of the text examines the innate and adaptive immune systems, the roles of different immune responses in combatting infection, the mechanisms by which infectious agents invade or subvert immune responses and the most effective ways of enhancing or selectively inducing different immune responses. The authors also discuss vaccine design, including peptide-based vaccines, rDNA technology, genetic (DNA) preparations and methods for producing vaccine perparations in plants. The final section explores the prospects of immunotherapy for tumours, autoimmune diseases and fertility control.

Human Vaccines

Human Vaccines PDF Author: Kayvon Modjarrad
Publisher: Academic Press
ISBN: 0128025425
Category : Medical
Languages : en
Pages : 186

View

Book Description
Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics—among other disciplines—that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens. For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology. Introduces new topics in vaccine immunology in the context vaccine design and production Consolidates the growing body of knowledge on new vaccine technologies that have only emerged in the past 2 – 3 decades Reviews the currently licensed vaccines that have utilized leading-edge technologies and how this has translated into improved efficacy and safety Provides a broad overview of innovative vaccine technologies, including immunological aspects